Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in childrenArticle Published on 2022-12-202023-07-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), [키워드] COVID-19 multisystem inflammatory syndrome in children neutrophil Neutrophil extracellular traps pediatrics. RNA sequencing [DOI] 10.1016/j.xcrm.2022.100848 PMC 바로가기
SARS-CoV-2 infection dynamics revealed by wastewater sequencing analysis and deconvolutionArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Accuracy analyses Analysis approach automated B.1.617.2 Berlin can be used changes in circulating computational analysis concern continuous monitoring COVID-19 COVID-19 surveillance Critical dataset detect develop effort environmental monitoring Health highlight identify in silico in-depth analysis include independent individual Infection infection rate Lineage MONITOR Mutation New York City pathogen proportion provide Public Public health risk raw data RBD RNA sequencing SARS-CoV-2 SARS-COV-2 infection sequenced Sequencing Sequencing analysis sequencing data sewage Sewage sampling. shown Support virus viruses VoC while [DOI] 10.1016/j.scitotenv.2022.158931 PMC 바로가기
Current trends in COVID-19 diagnosis and its new variants in physiological fluids: Surface antigens, antibodies, nucleic acids, and RNA sequencingReview article Published on 2022-12-012022-10-05 Journal: TrAC Trends in Analytical Chemistry [Category] 바이오마커, 변종, 진단, 치료기술, [키워드] addressed antibodies antibody Antigen antigens Beta Biomarker biosensors Blood body fluid circulation clustered regularly interspaced short palindromic repeats COVID-19 COVID-19 diagnosis COVID-19 virus diagnosis CRISPR Critical current Delta Detection sensitivity diagnostic early stage ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Gamma Infection isothermal amplification lateral flow immunoassay LFIA limit Loop-mediated isothermal amplification microarray analysis Microarray assays Mutation nucleic acid nucleic acids omicron outbreak overcome palindromic repeat physiological provide Rapid reduce reverse transcriptase-polymerase chain reaction reverse transcription RNA sequencing RT-LAMP RT-PCR Saliva SARS-CoV-2 Semen specificity Spread surface Urine variant variants virus viruses [DOI] 10.1016/j.trac.2022.116750 [Article Type] Review article
Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in ArkansasArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Affect approach Arkansas association Asymptomatic changes in Community complementary contribute coronavirus COVID-19 COVID-19 case COVID-19 testing death detect diagnostic Factors fecal genetic diversity Genetic variant genomic change highlight identity infected individual investigated nucleocapsid ORF1ab polymerase chain polyprotein public health quantified Quantitative recorded RNA sequencing RT-qPCR RT-qPCR assay SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutations SARS-CoV-2 RNA SARS-CoV-2 variant sensitivity silent Support Surface glycoprotein Surveillance TaqMan assay target Temporal the disease transmission of SARS-CoV-2 variants variants of concern viral gene viral titer virus virus genome was used wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157546 PMC 바로가기
Genome-wide detection of human variants that disrupt intronic branchpointsArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] Alter approach branchpoint Candidates characterized comparable COVID-19 Critical database demonstrated detect disease Disease genetics disrupt disrupting eight elements enzyme exonic feature heterozygous human gene human population identify initiated intron Intronic intronic variant ITPKB lymphoma machine-learning motif nucleotides upstream pathogenic Patient Pneumonia rare variant reported RNA sequencing RNA splicing sequencing data single-nucleotide Software splicing. STAT2 utility variant variants Variation [DOI] 10.1073/pnas.2211194119 PMC 바로가기
Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patientsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome antibody profiling blood sample cell death circulating neutrophil contributing to Control coronavirus COVID-19 degranulation disease disease severity driver dysregulated elevated experiment functions G-MDSC gene expression signature Granulocytic healthy donor hospitalized COVID-19 hospitalized COVID-19 patient Humoral response identify IgA IgA antibody IgG antibody Immunoglobulin induce longitudinal Mortality NETosis neutrophil Neutrophils Patient phagocytosis phenotype plasma plasma proteomics response RNA sequencing SARS-CoV-2 severe coronavirus disease severe COVID-19 severe disease Severe patient severity Subtypes survived transcriptomics transcriptomics. [DOI] 10.1016/j.xcrm.2022.100779 PMC 바로가기
Induction of Hypoxic Response in Caco-2 Cells Promote the Expression of Genes Involved in SARS-CoV-2 Endocytosis and TranscytosisArticle Published on 2022-10-012022-11-16 Journal: Doklady. Biochemistry and biophysics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 analyzed Caco-2 Caco-2 cell downregulation elevated endocytosis expression expression level expression of gene hypoxia hypoxic include increase in induction intestine involved LDL LDLR low-density LRP1 LRP4 LRP5 manuscript mechanism miRNA mRNA oxyquinoline receptor response RNA sequencing SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 viral particles significant increase TFRC Transcriptome Transcriptome. transcytosis Transport treated upregulation [DOI] 10.1134/S1607672922050118 PMC 바로가기
Single-nucleus RNA sequencing reveals the shared mechanisms inducing cognitive impairment between COVID-19 and Alzheimer’s diseaseArticle Published on 2022-09-232022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] AD-high-risk scores Alzheimer’s disease Astrocyte Cell cell population cognitive Cognitive impairment COVID-19 COVID-19 patients demonstrated disease disease-associated dysfunction GWAS identify mechanism Neuroinflammation Neuron neuronal pathway proteomic reported reveal RNA sequencing RNA-sequencing SARS-CoV-2 SARS-COV-2 infection single-nucleus RNA sequencing. subtype synaptic syndrome target therapeutic intervention transcriptomic [DOI] 10.3389/fimmu.2022.967356 PMC 바로가기
Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] activated Admission Alpha Biomarkers Blood Cohort COVID-19 COVID-19 pandemic Critical care defined EGFR epidermal expression First wave Gene Expression gene expression signature gene signature growth factor healthcare Healthcare system hospital hospitalised hospitalised patient ICU admission individual information intensive care intensive care unit naïve outcomes pathway Patient patients with COVID-19 peroxisome predict predicted Predictive Prognosis prognostic receptor resource RNA RNA sequencing RNA-Seq RNA-seq - RNA sequencing ROC tested TGF-β topological data analysis Topology Transcriptome Transcriptome. transforming growth factor Treatment was measured Whole blood with COVID-19 [DOI] 10.3389/fimmu.2022.988685 PMC 바로가기
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19Article Published on 2022-09-062022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq single-cell RNA-seq. Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection [DOI] 10.1073/pnas.2120680119 PMC 바로가기